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| Drug Name | GSK126 |
| Trade Name | |
| Synonyms | GSK2816126|GSK-126 |
| Drug Descriptions |
GSK126 selectively inhibits EZH2, resulting in decreased H3K27 tri-methylation, and potentially leading to decreased tumor cell proliferation and reduced tumor growth (PMID: 23051747, PMID: 25686104, PMID: 31471312). |
| DrugClasses | EZH2 inhibitor 20 |
| CAS Registry Number | 1346574-57-9 |
| NCIT ID | C113334 |
| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| ACY-957 + GSK126 | ACY-957 GSK126 | 0 | 0 |
| AZD1390 + GSK126 | AZD1390 GSK126 | 0 | 0 |
| Dexamethasone + GSK126 | Dexamethasone GSK126 | 0 | 0 |
| GSK126 | GSK126 | 1 | 1 |
| GSK126 + KU-60019 | GSK126 KU-60019 | 0 | 0 |
| GSK126 + Lenalidomide | GSK126 Lenalidomide | 0 | 0 |
| GSK126 + Olaparib | GSK126 Olaparib | 0 | 0 |
| GSK126 + Pictilisib | GSK126 Pictilisib | 0 | 0 |
| GSK126 + Pomalidomide | GSK126 Pomalidomide | 0 | 0 |