Avapritinib
Drug Detail
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| Drug Name | Avapritinib |
| Trade Name | Ayvakit |
| Synonyms | BLU-285 |
| Drug Descriptions |
Ayvakit (avapritinib) is a selective inhibitor of PDGFRA D842V and KIT exon 17 mutants, including KIT D816V, potentially resulting in decreased tumor growth (PMID: 30274985). Ayvakit (avapritinib) is FDA approved for use in patients with unresectable or metastatic gastrointestinal stromal tumor harboring a PDGFRA exon 18 mutation, including D842V, and in patients with advanced systemic mastocytosis (FDA.gov). |
| DrugClasses | KIT Inhibitor 57 PDGFR-alpha Inhibitor 10 |
| CAS Registry Number | 1703793-34-3 |
| NCIT ID | C123827 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Adavosertib + Avapritinib | Adavosertib Avapritinib | 2 | 0 |
| Avapritinib | Avapritinib | 70 | 8 |
| Avapritinib + Decitabine | Avapritinib Decitabine | 0 | 1 |
| Avapritinib + Decitabine and Cedazuridine | Avapritinib Decitabine and Cedazuridine | 0 | 1 |
| Avapritinib + Midazolam | Avapritinib Midazolam | 0 | 1 |
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