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Drug Name | Motolimod |
Trade Name | |
Synonyms | VTX-2337|VTX-378 |
Drug Descriptions |
Motolimod (VTX-2337) binds to and activates Toll-like receptor 8 (TLR8), resulting in enhanced antibody-dependent cell-mediated cytotoxicity (PMID: 22128302, PMID: 28453702, PMID: 29931076). |
DrugClasses | TLR8 Agonist 9 |
CAS Registry Number | 926927-61-9 |
NCIT ID | C80521 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Aldoxorubicin + Durvalumab + Motolimod | Aldoxorubicin Durvalumab Motolimod | 0 | 1 |
Cetuximab + Motolimod | Cetuximab Motolimod | 0 | 0 |
Cyclophosphamide + Motolimod + Pegfilgrastim | Cyclophosphamide Motolimod Pegfilgrastim | 0 | 1 |
Motolimod | Motolimod | 0 | 1 |
Motolimod + Nivolumab | Motolimod Nivolumab | 0 | 2 |
Motolimod + Pegylated liposomal doxorubicin | Motolimod Pegylated liposomal doxorubicin | 0 | 0 |