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Drug Name Motolimod
Trade Name
Synonyms VTX-2337|VTX-378
Drug Descriptions

Motolimod (VTX-2337) binds to and activates Toll-like receptor 8 (TLR8), resulting in enhanced antibody-dependent cell-mediated cytotoxicity (PMID: 22128302, PMID: 28453702, PMID: 29931076).

DrugClasses TLR8 Agonist 9
CAS Registry Number 926927-61-9
NCIT ID C80521

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Aldoxorubicin + Durvalumab + Motolimod Aldoxorubicin Durvalumab Motolimod 0 1
Cetuximab + Motolimod Cetuximab Motolimod 0 0
Cyclophosphamide + Motolimod + Pegfilgrastim Cyclophosphamide Motolimod Pegfilgrastim 0 1
Motolimod Motolimod 0 1
Motolimod + Nivolumab Motolimod Nivolumab 0 2
Motolimod + Pegylated liposomal doxorubicin Motolimod Pegylated liposomal doxorubicin 0 0


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