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Drug Name | Vocimagene amiretrorepvec |
Trade Name | |
Synonyms | T5.0002|Toca 511|DB107-RRV |
Drug Descriptions |
Vocimagene amiretrorepvec (DB107-RRV) is a retroviral vector encoding yeast cytosine deaminase, which converts the prodrug flucytosine into 5-fluorouracil upon infection of tumor cells, potentially leading to tumor cell death (PMID: 22547150, PMID: 30676111). |
DrugClasses | Chemotherapy - Antimetabolite 14 |
CAS Registry Number | 1300724-82-6 |
NCIT ID | C91734 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Temozolomide + Toca FC + Vocimagene amiretrorepvec | Temozolomide Toca FC Vocimagene amiretrorepvec | 0 | 1 |
Toca FC + Vocimagene amiretrorepvec | Toca FC Vocimagene amiretrorepvec | 0 | 5 |
Vocimagene amiretrorepvec | Vocimagene amiretrorepvec | 0 | 1 |