Therapy Detail
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| Therapy Name | Toca FC + Vocimagene amiretrorepvec |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Toca FC | DB107-FC|DB107FC | Chemotherapy - Antimetabolite 14 | Toca FC (DB107-FC) is an extended release form of flucytosine, which inhibits DNA synthesis after conversion to 5-fluorouracil (PMID: 30676111). | |
| Vocimagene amiretrorepvec | T5.0002|Toca 511|DB107-RRV | Chemotherapy - Antimetabolite 14 | Vocimagene amiretrorepvec (DB107-RRV) is a retroviral vector encoding yeast cytosine deaminase, which converts the prodrug flucytosine into 5-fluorouracil upon infection of tumor cells, potentially leading to tumor cell death (PMID: 22547150, PMID: 30676111). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06504381 | Phase Ib/II | Toca FC + Vocimagene amiretrorepvec Temozolomide + Toca FC + Vocimagene amiretrorepvec | DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma | Not yet recruiting | USA | 0 |
| NCT02576665 | Phase I | Toca FC + Vocimagene amiretrorepvec | A Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Subjects With Solid Tumors (Toca6) | Terminated | USA | 0 |
| NCT01156584 | Phase I | Toca FC + Vocimagene amiretrorepvec | A Study of a Retroviral Replicating Vector Administered to Subjects With Recurrent Malignant Glioma | Completed | USA | 0 |
| NCT06264388 | Phase II | Toca FC + Vocimagene amiretrorepvec | DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma | Recruiting | USA | 0 |
| NCT02414165 | Phase II | Bevacizumab Lomustine Toca FC + Vocimagene amiretrorepvec Temozolomide | P2/3 Randomized Study of Toca 511 & Toca FC Versus SOC in Subjects Undergoing Surgery for Recurrent GBM/AA (Toca5) | Terminated | USA | ISR | CAN | 1 |
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