TW-37
Drug Detail
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| Drug Name | TW-37 |
| Trade Name | |
| Synonyms | |
| Drug Descriptions |
TW-37 is a third-generation BH3 mimetic that inhibits BCL2, MCL1, and with lesser affinity, BCL-XL, which may result in increased tumor cell apoptosis and increased sensitivity to chemotherapeutics (PMID: 17404107, PMID: 32257914). |
| DrugClasses | BCL-XL inhibitor 14 BCL2 inhibitor 29 MCL1 Inhibitor 18 |
| CAS Registry Number | 877877-35-5 |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Trametinib + TW-37 | TW-37 Trametinib | 2 | 0 |
| TW-37 | TW-37 | 0 | 0 |
| TW-37 + Vemurafenib | TW-37 Vemurafenib | 2 | 0 |
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