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Drug Name | ABC294640 |
Trade Name | |
Synonyms | Yeliva|Opaganib|ABC-294640|ABC 294640 |
Drug Descriptions |
Yeliva (ABC294640) is a selective inhibitor of sphingokinase 2 (SK2), which results in decreased SK2 activity, leading to reduced cell signaling and tumor cell growth (PMID: 26271487, PMID: 32626514, PMID: 32670862). |
DrugClasses | |
CAS Registry Number | 915385-81-8 |
NCIT ID | C98278 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
ABC294640 | ABC294640 | 0 | 4 |
ABC294640 + Abiraterone | ABC294640 Abiraterone | 0 | 1 |
ABC294640 + Enzalutamide | ABC294640 Enzalutamide | 0 | 1 |
ABC294640 + Gemcitabine | ABC294640 Gemcitabine | 0 | 0 |