ARQ761
Drug Detail
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| Drug Name | ARQ761 |
| Trade Name | |
| Synonyms | beta-lapachone|ARQ-761 |
| Drug Descriptions |
ARQ761 (beta-lapachone) is metabolized intracellularly by NQO1, generating reactive oxygen species, which leads to DNA damage and PARP1 hyperactivation and potentially results in increased death of NQO1-expressing tumor cells (PMID: 26602448, PMID: 31858276, PMID: 30617135). |
| DrugClasses | |
| CAS Registry Number | NA |
| NCIT ID | C99146 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| ARQ761 | ARQ761 | 0 | 0 |
| ARQ761 + Telaglenastat | ARQ761 Telaglenastat | 0 | 0 |
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