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Drug Name | ARQ761 |
Trade Name | |
Synonyms | beta-lapachone|ARQ-761 |
Drug Descriptions |
ARQ761 (beta-lapachone) is metabolized intracellularly by NQO1, generating reactive oxygen species, which leads to DNA damage and PARP1 hyperactivation and potentially results in increased death of NQO1-expressing tumor cells (PMID: 26602448, PMID: 31858276, PMID: 30617135). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C99146 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
ARQ761 | ARQ761 | 0 | 0 |
ARQ761 + Telaglenastat | ARQ761 Telaglenastat | 0 | 0 |