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Drug Name | Linrodostat |
Trade Name | |
Synonyms | BMS986205|BMS 986205|ONO-7701|BMS-986205 |
Drug Descriptions |
Linrodostat (BMS-986205) inhibits indoleamine 2,3-dioxygenase 1 (IDO1), which results in decreased breakdown of tryptophan into kynurenine in the tumor microenvironment, potentially resulting in enhanced anti-tumor immune response (PMID: 31823654, PMID: 33298590). |
DrugClasses | IDO1 Inhibitor 12 |
CAS Registry Number | 1923833-60-6 |
NCIT ID | C141135 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
BCG solution + Linrodostat + Nivolumab | BCG solution Linrodostat Nivolumab | 0 | 1 |
Cisplatin + Gemcitabine + Linrodostat + Nivolumab | Cisplatin Gemcitabine Linrodostat Nivolumab | 0 | 1 |
Ipilimumab + Linrodostat + Nivolumab | Ipilimumab Linrodostat Nivolumab | 0 | 1 |
Linrodostat | Linrodostat | 0 | 0 |
Linrodostat + Nivolumab | Linrodostat Nivolumab | 0 | 12 |
Linrodostat + Nivolumab + Relatlimab | Linrodostat Nivolumab Relatlimab | 0 | 1 |
Linrodostat + Nivolumab + Temozolomide | Linrodostat Nivolumab Temozolomide | 0 | 1 |