Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name Linrodostat
Trade Name
Synonyms BMS986205|BMS 986205|ONO-7701|BMS-986205
Drug Descriptions

Linrodostat (BMS-986205) inhibits indoleamine 2,3-dioxygenase 1 (IDO1), which results in decreased breakdown of tryptophan into kynurenine in the tumor microenvironment, potentially resulting in enhanced anti-tumor immune response (PMID: 31823654, PMID: 33298590).

DrugClasses IDO1 Inhibitor 12
CAS Registry Number 1923833-60-6
NCIT ID C141135

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
BCG solution + Linrodostat + Nivolumab BCG solution Linrodostat Nivolumab 0 1
Cisplatin + Gemcitabine + Linrodostat + Nivolumab Cisplatin Gemcitabine Linrodostat Nivolumab 0 1
Ipilimumab + Linrodostat + Nivolumab Ipilimumab Linrodostat Nivolumab 0 1
Linrodostat Linrodostat 0 0
Linrodostat + Nivolumab Linrodostat Nivolumab 0 12
Linrodostat + Nivolumab + Relatlimab Linrodostat Nivolumab Relatlimab 0 1
Linrodostat + Nivolumab + Temozolomide Linrodostat Nivolumab Temozolomide 0 1


Additional content available in CKB BOOST