LCL161
Drug Detail
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| Drug Name | LCL161 |
| Trade Name | |
| Synonyms | LCL-161|LCL 161 |
| Drug Descriptions |
LCL161 is a SMAC mimetic that inhibits Inhibitor of Apoptosis Protein (IAP) family proteins, potentially leading to increased tumor cell death (PMID: 21681929, PMID: 24976294, PMID: 25113756). |
| DrugClasses | SMAC Mimetic 8 |
| CAS Registry Number | 1005342-46-0 |
| NCIT ID | C91079 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Cyclophosphamide + LCL161 | Cyclophosphamide LCL161 | 0 | 1 |
| LCL161 | LCL161 | 0 | 1 |
| LCL161 + Paclitaxel | LCL161 Paclitaxel | 0 | 0 |
| LCL161 + Spartalizumab | LCL161 Spartalizumab | 0 | 2 |
| LCL161 + Topotecan | LCL161 Topotecan | 0 | 1 |
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