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Drug Name Spartalizumab
Trade Name
Synonyms PDR001|PDR-001
Drug Descriptions

Spartalizumab (PDR001) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 32364844, PMID: 32179633).

DrugClasses Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121
CAS Registry Number 1935694-88-4
NCIT ID C121625

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Therapy Name Drugs Efficacy Evidence Clinical Trials
BLZ945 + Spartalizumab BLZ945 Spartalizumab 0 1
Canakinumab + Carboplatin + Spartalizumab Canakinumab Carboplatin Spartalizumab 0 1
Canakinumab + Cisplatin + Pemetrexed Disodium + Spartalizumab Canakinumab Cisplatin Pemetrexed Disodium Spartalizumab 0 1
Canakinumab + Gemcitabine + Nab-paclitaxel + Spartalizumab Canakinumab Gemcitabine Nab-paclitaxel Spartalizumab 0 1
Canakinumab + Ieramilimab + Spartalizumab Canakinumab Ieramilimab Spartalizumab 0 1
Canakinumab + Spartalizumab Canakinumab Spartalizumab 0 3
Capmatinib + Ieramilimab + Spartalizumab Capmatinib Ieramilimab Spartalizumab 0 1
Capmatinib + Spartalizumab Capmatinib Spartalizumab 0 5
Carboplatin + Cisplatin + Pemetrexed Disodium + Spartalizumab Carboplatin Cisplatin Pemetrexed Disodium Spartalizumab 0 0
Carboplatin + Ieramilimab + Spartalizumab Carboplatin Ieramilimab Spartalizumab 0 1
Carboplatin + Paclitaxel + Spartalizumab Carboplatin Paclitaxel Spartalizumab 0 1
Cisplatin + Gemcitabine + Spartalizumab Cisplatin Gemcitabine Spartalizumab 0 1
Cisplatin + Pemetrexed Disodium + Spartalizumab Cisplatin Pemetrexed Disodium Spartalizumab 0 1
CJM112 + Spartalizumab CJM112 Spartalizumab 0 2
Dabrafenib + LTT462 + Spartalizumab Dabrafenib LTT462 Spartalizumab 0 1
Dabrafenib + Spartalizumab Dabrafenib Spartalizumab 0 1
Dabrafenib + Spartalizumab + Trametinib Dabrafenib Spartalizumab Trametinib 2 3
Decitabine + Sabatolimab + Spartalizumab Decitabine Sabatolimab Spartalizumab 0 1
Decitabine + Spartalizumab Decitabine Spartalizumab 0 1
DFF332 + Spartalizumab + Taminadenant DFF332 Spartalizumab Taminadenant 0 1
DKY709 + Spartalizumab DKY709 Spartalizumab 0 1
Everolimus + Spartalizumab Everolimus Spartalizumab 0 1
FAZ053 + Spartalizumab FAZ053 Spartalizumab 0 1
Fulvestrant + Ribociclib + Spartalizumab Fulvestrant Ribociclib Spartalizumab 0 1
Gemcitabine + Nab-paclitaxel + NIS793 + Spartalizumab Gemcitabine NIS793 Nab-paclitaxel Spartalizumab 0 1
GWN 323 + Spartalizumab GWN 323 Spartalizumab 0 1
Ieramilimab + MCS110 + Spartalizumab Ieramilimab MCS110 Spartalizumab 0 1
Ieramilimab + Spartalizumab Ieramilimab Spartalizumab 0 2
Ieramilimab + Spartalizumab + Taminadenant Ieramilimab Spartalizumab Taminadenant 0 1
Imatinib + Spartalizumab Imatinib Spartalizumab 2 0
JDQ443 + Spartalizumab JDQ443 Spartalizumab 0 0
JDQ443 + Spartalizumab + TNO155 JDQ443 Spartalizumab TNO155 0 0
KAZ954 + Spartalizumab KAZ954 Spartalizumab 0 1
LCL161 + Spartalizumab LCL161 Spartalizumab 0 2
LGK974 + Spartalizumab LGK974 Spartalizumab 0 1
LHC165 + Spartalizumab LHC165 Spartalizumab 0 1
LXH 254 + Spartalizumab LXH 254 Spartalizumab 0 1
MCS110 + Spartalizumab MCS110 Spartalizumab 0 1
MIW815 + Spartalizumab MIW815 Spartalizumab 0 1
Nazartinib + Spartalizumab Nazartinib Spartalizumab 0 1
NIS793 + Spartalizumab NIS793 Spartalizumab 0 1
NIZ985 + Spartalizumab NIZ985 Spartalizumab 0 2
NZV930 + Spartalizumab NZV930 Spartalizumab 0 1
NZV930 + Spartalizumab + Taminadenant NZV930 Spartalizumab Taminadenant 0 1
Panobinostat + Spartalizumab Panobinostat Spartalizumab 0 1
Pazopanib + Spartalizumab Pazopanib Spartalizumab 0 1
Regorafenib + Spartalizumab Regorafenib Spartalizumab 0 1
Ribociclib + Spartalizumab Ribociclib Spartalizumab 0 1
Sabatolimab + Spartalizumab Sabatolimab Spartalizumab 0 1
Siltuximab + Spartalizumab Siltuximab Spartalizumab 0 1
Sorafenib + Spartalizumab Sorafenib Spartalizumab 0 1
Spartalizumab Spartalizumab 0 10
Spartalizumab + Taminadenant Spartalizumab Taminadenant 0 2
Spartalizumab + TNO155 Spartalizumab TNO155 0 1
Spartalizumab + Trametinib Spartalizumab Trametinib 0 2


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