PT2385
Drug Detail
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| Drug Name | PT2385 |
| Trade Name | |
| Synonyms | |
| Drug Descriptions |
PT2385 is a hypoxia inducible factor-2alpha (EPAS1, HIF2A) inhibitor that leads to dissociation of HIF-2 complexes, thereby suppressing expression of HIF2A target genes, and potentially resulting in antitumor activity (PMID: 31727677). |
| DrugClasses | HIF2A Inhibitor 6 |
| CAS Registry Number | 1672665-49-4 |
| NCIT ID | C119618 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Nivolumab + PT2385 | Nivolumab PT2385 | 0 | 1 |
| PT2385 | PT2385 | 0 | 3 |
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