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Drug Name | TAS-114 |
Trade Name | |
Synonyms | TAS 114|TAS114 |
Drug Descriptions |
TAS-114 is a dual inhibitor of deoxyuridine triphosphatase (dUTPase) and dihydropyrimidine dehydrogenase (DPD), which may enhance anti-tumor activity of 5-FU through modulating its metabolism (PMID: 24452393, PMID: 30511200, PMID: 32700159, PMID: 32246224). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C116885 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Capecitabine + TAS-114 | Capecitabine TAS-114 | 0 | 1 |
TAS-114 | TAS-114 | 0 | 0 |
TAS-114 + Tegafur-gimeracil-oteracil Potassium | TAS-114 Tegafur-gimeracil-oteracil Potassium | 0 | 1 |