Taletrectinib
Drug Detail
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| Drug Name | Taletrectinib |
| Trade Name | Ibtrozi |
| Synonyms | DS6051b|DS-6051B|DS-6051|AB-106 |
| Drug Descriptions |
Ibtrozi (taletrectinib) is an inhibitor of NTRK1/2/3 and ROS1 fusion proteins, which blocks downstream signaling and may lead to inhibition of tumor cell growth (PMID: 32591465). Ibtrozi (taletrectinib) is FDA-approved for use in patients with locally advanced or metastatic ROS1-positive non-small cell lung cancer (FDA.gov). |
| DrugClasses | ROS1 Inhibitor 23 Trk Receptor Inhibitor (Pan) 33 |
| CAS Registry Number | 1505515-69-4 |
| NCIT ID | C118948 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| SHP099 + Taletrectinib | SHP099 Taletrectinib | 0 | 0 |
| Taletrectinib | Taletrectinib | 9 | 4 |
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