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Drug Name | Baicalein |
Trade Name | |
Synonyms | |
Drug Descriptions |
Baicalein is a plant-derived small molecule that binds to Msh2 and mismatched DNA and inhibits the interaction between Msh2 and Chk1/Atm, resulting in increased double-strand breaks and cell death in mismatch repair-deficient tumor cells (PMID: 27262172), and induces DDIT4 expression, which leads to inhibition of mTORC1 activity (PMID: 25543165, PMID: 32800561). |
DrugClasses | |
CAS Registry Number | 491-67-8 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Baicalein | Baicalein | 2 | 0 |