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Drug Name Baicalein
Trade Name
Synonyms
Drug Descriptions

Baicalein is a plant-derived small molecule that binds to Msh2 and mismatched DNA and inhibits the interaction between Msh2 and Chk1/Atm, resulting in increased double-strand breaks and cell death in mismatch repair-deficient tumor cells (PMID: 27262172), and induces DDIT4 expression, which leads to inhibition of mTORC1 activity (PMID: 25543165, PMID: 32800561).

DrugClasses
CAS Registry Number 491-67-8
NCIT ID NA

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Baicalein Baicalein 2 0


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