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Drug Name | CX-5461 |
Trade Name | |
Synonyms | CX5461|Pidnarulex|CX 5461 |
Drug Descriptions |
CX-5461 is an RNA polymerase I (Pol I) inhibitor that inhibits rRNA synthesis, resulting in growth arrest and apoptosis in cancer cells (PMID: 26472108, PMID: 32719798). |
DrugClasses | |
CAS Registry Number | 1138549-36-6 |
NCIT ID | C126798 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
CX-5461 | CX-5461 | 1 | 1 |
CX-5461 + CX-6258 | CX-5461 CX-6258 | 1 | 0 |
CX-5461 + Talazoparib | CX-5461 Talazoparib | 0 | 1 |