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Drug Name CX-5461
Trade Name
Synonyms CX5461|Pidnarulex|CX 5461
Drug Descriptions

CX-5461 is an RNA polymerase I (Pol I) inhibitor that inhibits rRNA synthesis, resulting in growth arrest and apoptosis in cancer cells (PMID: 26472108, PMID: 32719798).

DrugClasses
CAS Registry Number 1138549-36-6
NCIT ID C126798

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Therapy Name Drugs Efficacy Evidence Clinical Trials
CX-5461 CX-5461 1 1
CX-5461 + CX-6258 CX-5461 CX-6258 1 0
CX-5461 + Talazoparib CX-5461 Talazoparib 0 1


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