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Drug Name | GSK3174998 |
Trade Name | |
Synonyms | GSK-3174998|GSK 3174998 |
Drug Descriptions |
GSK3174998 is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response (Cancer Res July 15 2016 (76) (14 Supplement) CT027). |
DrugClasses | OX40 Antibody 14 |
CAS Registry Number | 2089398-68-3 |
NCIT ID | C124783 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
belantamab mafodotin-blmf + GSK3174998 | GSK3174998 belantamab mafodotin-blmf | 0 | 1 |
GSK1795091 + GSK3174998 | GSK1795091 GSK3174998 | 0 | 1 |
GSK3174998 | GSK3174998 | 0 | 2 |
GSK3174998 + Pembrolizumab | GSK3174998 Pembrolizumab | 0 | 0 |