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Drug Name | Zotiraciclib |
Trade Name | |
Synonyms | SB1317|TG02 |
Drug Descriptions |
Zotiraciclib (TG02) is a pyrimidine-based molecule that inhibits CDK1, CDK2, CDK3, CDK5, CDK7, CDK9, JAK2, and FLT3, which results in growth inhibition in tumor cells (PMID: 21860433). |
DrugClasses | CDK1 Inhibitor 13 CDK2 Inhibitor 31 CDK5 Inhibitor 8 CDK7 Inhibitor 16 CDK9 Inhibitor 21 FLT3 Inhibitor 69 JAK2 Inhibitor 19 |
CAS Registry Number | 937270-47-8 |
NCIT ID | C105851 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Carfilzomib + Zotiraciclib | Carfilzomib Zotiraciclib | 0 | 0 |
Radiotherapy + Zotiraciclib | Radiotherapy Zotiraciclib | 0 | 1 |
Temozolomide + Zotiraciclib | Temozolomide Zotiraciclib | 0 | 2 |
Zotiraciclib | Zotiraciclib | 1 | 3 |