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Drug Name | Carfilzomib |
Trade Name | Kyprolis |
Synonyms | PR-171 |
Drug Descriptions |
Kyprolis (carfilzomib) binds to the 20S proteasome and inhibits its protein degradation activity, thereby leading to the accumulation of ubiquinated proteins, which may result in apoptosis and growth arrest in tumor cells (PMID: 26893241). Kyprolis (carfilzomib) in combination with lenalidomide and dexamethasone, or in combination with Darzalex Faspro (Daratumumab and hyaluronidase-fihj) and dexamethasone is FDA-approved for use in patients with multiple myeloma (FDA.gov). |
DrugClasses | |
CAS Registry Number | 868540-17-4 |
NCIT ID | C52196 |