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Drug Name | Tisotumab vedotin-tftv |
Trade Name | Tivdak |
Synonyms | HuMax-TF-ADC|TF-011-MMAE |
Drug Descriptions |
Tivdak (tisotumab vedotin-tftv) is an antibody-drug conjugate consists of anti-tissue factor (TF) antibody and the cytotoxic agent monomethyl auristatin E (MMAE), which induces killing of tumor cells overexpressing tissue factor (PMID: 24371232, PMID: 31796521). Tivdak (tisotumab vedotin-tftv) is FDA approved fro use in patients with with recurrent or metastatic cervical cancer (FDA.gov). |
DrugClasses | |
CAS Registry Number | 1418731-10-8 |
NCIT ID | C113164 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Bevacizumab + Tisotumab vedotin-tftv | Bevacizumab Tisotumab vedotin-tftv | 0 | 1 |
Carboplatin + Tisotumab vedotin-tftv | Carboplatin Tisotumab vedotin-tftv | 0 | 1 |
Pembrolizumab + Tisotumab vedotin-tftv | Pembrolizumab Tisotumab vedotin-tftv | 0 | 1 |
Tisotumab vedotin-tftv | Tisotumab vedotin-tftv | 0 | 6 |