AMG 176
Drug Detail
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| Drug Name | AMG 176 |
| Trade Name | |
| Synonyms | Tapotoclax|AMG-176|AMG176 |
| Drug Descriptions |
Tapotoclax (AMG 176) selectively inhibits MCL1, potentially resulting in increased tumor cell apoptosis (PMID: 31937611) and reduced tumor growth (PMID: 30254093). |
| DrugClasses | MCL1 Inhibitor 18 |
| CAS Registry Number | 1883727-34-1 |
| NCIT ID | C127817 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| AMG 176 | AMG 176 | 0 | 2 |
| AMG 176 + Azacitidine | AMG 176 Azacitidine | 0 | 1 |
| AMG 176 + Selumetinib | AMG 176 Selumetinib | 1 | 0 |
| AMG 176 + Trametinib | AMG 176 Trametinib | 1 | 0 |
| AMG 176 + Venetoclax | AMG 176 Venetoclax | 0 | 1 |
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