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Therapy Name AMG 176 + Venetoclax
Synonyms
Therapy Description

AMG 176 selectively binds and inhibits Mcl1, which results in activation of apoptotic signaling, potentially leading to decreased tumor cell viability (Cancer Res July 1 2017 (77) (13 Supplement) 2027).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AMG 176 Tapotoclax|AMG-176|AMG176 MCL1 Inhibitor 18 Tapotoclax (AMG 176) selectively inhibits MCL1, potentially resulting in increased tumor cell apoptosis (PMID: 31937611) and reduced tumor growth (PMID: 30254093).
Venetoclax Venclexta ABT-199|RG7601|GDC-0199|ABT119|Venclyxto BCL2 inhibitor 27 Venclexta (venetoclax) is a BH3-mimetic that binds to and inhibits BCL2, resulting in increased tumor cell apoptosis (PMID: 26589495, PMID: 25048785). Venclexta (venetoclax) is FDA approved for use in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), and in combination with chemotherapy in patients 75 years old or older with newly-diagnosed acute myeloid leukemia (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03797261 Phase I AMG 176 + Venetoclax A Study of Venetoclax and AMG 176 in Patients With Relapsed/Refractory Hematologic Malignancies Terminated USA | DEU | AUS 0


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