Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Drug Name | ORY-1001 |
Trade Name | |
Synonyms | RO7051790|RO 7051790|RG6016|RG 6016|iadademstat |
Drug Descriptions |
ORY-1001 (iadademstat) binds to and inhibits KDM1A (LSD1), leading to increased H3K4 dimethylation and potentially resulting in increased differentiation and decreased growth of tumor cells (PMID: 29502954, PMID: 32191225). |
DrugClasses | KDM1A Inhibitor 15 |
CAS Registry Number | 1431304-21-0 |
NCIT ID | C131908 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Azacitidine + ORY-1001 | Azacitidine ORY-1001 | 0 | 1 |
Azacitidine + ORY-1001 + Venetoclax | Azacitidine ORY-1001 Venetoclax | 0 | 2 |
Gilteritinib + ORY-1001 | Gilteritinib ORY-1001 | 0 | 1 |
ORY-1001 | ORY-1001 | 0 | 0 |
ORY-1001 + Paclitaxel | ORY-1001 Paclitaxel | 0 | 1 |