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Drug Name ORY-1001
Trade Name
Synonyms RO7051790|RO 7051790|RG6016|RG 6016|iadademstat
Drug Descriptions

ORY-1001 (iadademstat) binds to and inhibits KDM1A (LSD1), leading to increased H3K4 dimethylation and potentially resulting in increased differentiation and decreased growth of tumor cells (PMID: 29502954, PMID: 32191225).

DrugClasses KDM1A Inhibitor 15
CAS Registry Number 1431304-21-0
NCIT ID C131908

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + ORY-1001 Azacitidine ORY-1001 0 1
Azacitidine + ORY-1001 + Venetoclax Azacitidine ORY-1001 Venetoclax 0 2
Gilteritinib + ORY-1001 Gilteritinib ORY-1001 0 1
ORY-1001 ORY-1001 0 0
ORY-1001 + Paclitaxel ORY-1001 Paclitaxel 0 1


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