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Drug Name | Belvarafenib |
Trade Name | |
Synonyms | HM95573|GDC-5573|RO7223619 |
Drug Descriptions |
Belvarafenib (HM95573) selectively inhibits RAF dimer formation, leading to inhibition of ARAF, BRAF, and CRAF activity, and potentially resulting in tumor growth inhibition (PMID: 33953400). |
DrugClasses | RAF Inhibitor (Pan) 28 |
CAS Registry Number | 1446113-23-0 |
NCIT ID | C121646 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Atezolizumab + Belvarafenib + Cobimetinib | Atezolizumab Belvarafenib Cobimetinib | 0 | 0 |
Belvarafenib | Belvarafenib | 19 | 1 |
Belvarafenib + Cobimetinib | Belvarafenib Cobimetinib | 5 | 1 |
Belvarafenib + Cobimetinib + Nivolumab | Belvarafenib Cobimetinib Nivolumab | 0 | 1 |