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Drug Name | PVSRIPO |
Trade Name | |
Synonyms | PVS-RIPO|NSC-719277|NSC719277 |
Drug Descriptions |
PVSRIPO is an oncolytic virus comprising a recombinant poliovirus/rhinovirus chimera, which targets CD155 (Necl5)-expressing tumor cells, and potentially induces enhanced anti-tumor immune response and tumor cell cytotoxicity (PMID: 21984883, PMID: 24939611). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C99459 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Atezolizumab + PVSRIPO | Atezolizumab PVSRIPO | 0 | 1 |
Lomustine + PVSRIPO | Lomustine PVSRIPO | 0 | 1 |
Nivolumab + PVSRIPO | Nivolumab PVSRIPO | 0 | 1 |
Pembrolizumab + PVSRIPO | PVSRIPO Pembrolizumab | 0 | 1 |
PVSRIPO | PVSRIPO | 0 | 5 |
PVSRIPO + unspecified PD-1 antibody | PVSRIPO unspecified PD-1 antibody | 0 | 2 |