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Drug Name | TPST-1120 |
Trade Name | |
Synonyms | TPST1120|TPST 1120 |
Drug Descriptions |
TPST-1120 is a peroxisome proliferator-activated receptor alpha (PPARa) antagonist, which inhibits transcription of PPAR alpha genes to alter fatty acid metabolism thereby inducing macrophages to an M1 phenotype for increased cytotoxicity (Journal of Clinical Oncology 37, no. 15_suppl., TPS2665). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C169105 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Atezolizumab + Bevacizumab + TPST-1120 | Atezolizumab Bevacizumab TPST-1120 | 0 | 0 |
Cetuximab + TPST-1120 | Cetuximab TPST-1120 | 0 | 1 |
Docetaxel + TPST-1120 | Docetaxel TPST-1120 | 0 | 1 |
Nivolumab + TPST-1120 | Nivolumab TPST-1120 | 0 | 1 |
TPST-1120 | TPST-1120 | 0 | 1 |