Therapy Detail
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| Therapy Name | Docetaxel + TPST-1120 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Docetaxel | Taxotere | RP56976 | Antimicrotubule Agent 14 | Taxotere (docetaxel) binds to tubulin, inhibiting microtubule disassembly and preventing cell division (PMID: 32496783, PMID: 32366558). |
| TPST-1120 | TPST1120|TPST 1120 | TPST-1120 is a peroxisome proliferator-activated receptor alpha (PPARa) antagonist, which inhibits transcription of PPAR alpha genes to alter fatty acid metabolism thereby inducing macrophages to an M1 phenotype for increased cytotoxicity (Journal of Clinical Oncology 37, no. 15_suppl., TPS2665). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03829436 | Phase I | TPST-1120 Nivolumab + TPST-1120 Docetaxel + TPST-1120 Cetuximab + TPST-1120 | TPST-1120 as Monotherapy and in Combination With (Nivolumab, Docetaxel or Cetuximab) in Subjects With Advanced Cancers | Completed | USA | 0 |
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