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Drug Name | Divalproex sodium |
Trade Name | Depakote |
Synonyms | Valproate semisodium|Sodium divalproex |
Drug Descriptions |
Depakote (Divalproex sodium) comprises a 1:1 mixture of valproic acid and sodium valproate, which acts as an HDAC inhibitor, potentially resulting in decreased growth and increased apoptosis of tumor cells in combination with other agents (PMID: 25449787, PMID: 20200483). Depakote (divalproex sodium) is FDA approved for treatment of manic episodes associated with bipolar disorder, as well as seizures, and migraines (FDA.gov). |
DrugClasses | HDAC Inhibitor 45 |
CAS Registry Number | 76584-70-8 |
NCIT ID | C28996 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cetuximab + Divalproex sodium + Panitumumab | Cetuximab Divalproex sodium Panitumumab | 0 | 0 |
Divalproex sodium | Divalproex sodium | 0 | 0 |
Divalproex sodium + Neratinib | Divalproex sodium Neratinib | 0 | 1 |