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| Drug Name | Neratinib |
| Trade Name | Nerlynx |
| Synonyms | HKI-272|PB272 |
| Drug Descriptions |
Nerlynx (neratinib) inhibits the ERBB2 (HER2) receptor as well as EGFR, resulting in decreased proliferation of HER2 and EGFR expressing tumor cells (PMID: 15173008). Nerlynx (neratinib) is FDA approved for use in patients with early stage ERBB2 (HER2)-positive breast cancer following Herceptin (trastuzumab)-based therapy, and in combination with Xeloda (capecitabine) in patients with advanced/metastatic ERBB2 (HER2)-positive breast cancer who have received two or more anti-ERBB2 (HER2) regimens (FDA.gov). |
| DrugClasses | HER2 Inhibitor 42 |
| CAS Registry Number | 915942-22-2 |
| NCIT ID | C136891 |
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