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Drug Name D2C7-IT
Trade Name
Synonyms D2C7-(scdsFv)-PE38KDEL
Drug Descriptions

D2C7-IT is an immunotoxin engineered by linking a fragment of the D2C7 monoclonal antibody recognizing wild-type EGFR and EGFRvIII with Pseudomonas Exotoxin A (PE38KDEL), which targets tumor cells expressing wild-type EGFR and/or EGFRvIII, potentially resulting in decreased tumor growth (PMID: 28286803, PMID: 31142380).

DrugClasses
CAS Registry Number NA
NCIT ID C119739

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Therapy Name Drugs Efficacy Evidence Clinical Trials
2141 V-11 + D2C7-IT 2141 V-11 D2C7-IT 0 3
Atezolizumab + D2C7-IT Atezolizumab D2C7-IT 0 1
D2C7-IT D2C7-IT 0 1


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