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Therapy Name 2141 V-11 + D2C7-IT
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
2141 V-11 2141 V11|2141-V11 CD40 Antibody 14 2141 V-11 is a human anti-CD40 antibody with modified Fc domain, which potentially enhances antitumor immune response and inhibits tumor growth (PMID: 30297432).
D2C7-IT D2C7-(scdsFv)-PE38KDEL D2C7-IT is an immunotoxin engineered by linking a fragment of the D2C7 monoclonal antibody recognizing wild-type EGFR and EGFRvIII with Pseudomonas Exotoxin A (PE38KDEL), which targets tumor cells expressing wild-type EGFR and/or EGFRvIII, potentially resulting in decreased tumor growth (PMID: 28286803, PMID: 31142380).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06455605 Phase Ib/II 2141 V-11 + D2C7-IT D2C7-IT + 2141-V11 Combination Post-resection in rGBM Not yet recruiting USA 0
NCT05734560 Phase Ib/II 2141 V-11 + D2C7-IT D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients Recruiting USA 0
NCT04547777 Phase I 2141 V-11 + D2C7-IT Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma Recruiting USA 0


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