Zotatifin
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| Drug Name | Zotatifin |
| Trade Name | |
| Synonyms | eFT226|eFT-226|eFT 226 |
| Drug Descriptions |
Zotatifin (eFT226) is an eukaryotic initiation factor 4A1 (eIF4A1) inhibitor that promotes binding of eIF4A1 to the 5'-UTR in a sequence selective manner, which leads to repression of mRNA translation, including translation of the receptor tyrosine kinases FGFR1/2 and ERBB2 (HER2), and potentially results in induction of apoptosis and inhibition of tumor growth (Mol Cancer Ther 2019;18(12 Suppl):Abstract nr B133, PMID: 32470302). |
| DrugClasses | |
| CAS Registry Number | 2098191-53-6 |
| NCIT ID | C165746 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Abemaciclib + Fulvestrant + Zotatifin | Abemaciclib Fulvestrant Zotatifin | 0 | 1 |
| Abemaciclib + Letrozole + Zotatifin | Abemaciclib Letrozole Zotatifin | 0 | 1 |
| Fulvestrant + Zotatifin | Fulvestrant Zotatifin | 0 | 1 |
| Sotorasib + Zotatifin | Sotorasib Zotatifin | 0 | 1 |
| Trastuzumab + Zotatifin | Trastuzumab Zotatifin | 0 | 1 |
| Zotatifin | Zotatifin | 2 | 1 |
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