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Drug Name | KPG-818 |
Trade Name | |
Synonyms | KPG818|KPG 818 |
Drug Descriptions |
KPG-818 targets cereblon (CRBN), a component of the CRL4-CRBN E3 ubiquitin ligase complex, and modifies its E3 ligase activity, which may lead to proteosomal degradation of T cell transcriptional repressors, potentially resulting in activation of immune response and decreased tumor cell proliferation (NCI Drug Dictionary). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C175979 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
KPG-818 | KPG-818 | 0 | 1 |