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Therapy Name | KPG-818 |
Synonyms | |
Therapy Description |
KPG-818 targets cereblon (CRBN), a component of the CRL4-CRBN E3 ubiquitin ligase complex, and modifies its E3 ligase activity, which may lead to proteosomal degradation of T cell transcriptional repressors, potentially resulting in activation of immune response and decreased tumor cell proliferation (NCI Drug Dictionary). |