Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name NUC-1031
Trade Name
Synonyms gemcitabine ProTide|Fosgemcitabine Palabenamide|NUC 1031|Acelarin
Drug Descriptions

NUC-1031 is a gemicitabine-derivative pyrimidine analogue prodrug that is converted into the products dFdCDP and dFdCTP, which reduce the nucleotide pool for DNA replication and inhibit DNA synthesis, respectively, potentially resulting in increased tumor cell apoptosis (PMID: 30206366, PMID: 31113993).

DrugClasses Chemotherapy - Antimetabolite 14
CAS Registry Number 840506-29-8
NCIT ID C102752

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Cisplatin + NUC-1031 Cisplatin NUC-1031 0 1
NUC-1031 NUC-1031 0 0


Additional content available in CKB BOOST