FT596
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| Drug Name | FT596 |
| Trade Name | |
| Synonyms | FT-596|FT 596 |
| Drug Descriptions |
FT596 consists of induced pluripotent stem cell (iPSC)-derived natural killer cells engineered to express a CD19 targeting chimeric antigen receptor (CAR), a fusion protein consisting of IL15 and IL-15R alpha, and CD16, which may lead to enhanced cytotoxicity in CD19-expressing tumor cells (Blood (2019) 134 (Supplement_1): 301). |
| DrugClasses | CD19 Immune Cell Therapy 72 |
| CAS Registry Number | NA |
| NCIT ID | C170800 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Cyclophosphamide + Fludarabine + FT596 | Cyclophosphamide FT596 Fludarabine | 0 | 1 |
| Cyclophosphamide + Fludarabine + FT596 + Obinutuzumab | Cyclophosphamide FT596 Fludarabine Obinutuzumab | 0 | 1 |
| Cyclophosphamide + Fludarabine + FT596 + Rituximab | Cyclophosphamide FT596 Fludarabine Rituximab | 0 | 1 |
| FT596 | FT596 | 0 | 0 |
| FT596 + Rituximab | FT596 Rituximab | 0 | 1 |
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