Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name Obinutuzumab
Trade Name Gazyva
Synonyms R7159|afutuzumab|GA101|GA-101|RO 5072759
Drug Descriptions

Gazyva (obinutuzumab) is a glycoengineered anti-CD20 antibody that binds to CD20 on B-cells, resulting in increased antibody-dependent cellular cytotoxicity and induction of apoptosis, and potentially leading to decreased growth of B-cell tumors (PMID: 20194898, PMID: 21220500). Gazyva (obinutuzumab) is FDA approved in combination with Ambochlorin (chlorambucil) for chronic lymphocytic leukemia and in combination with Treanda (bendamustine) or chemotherapy for follicular lymphoma (FDA.gov).

DrugClasses CD20 Antibody 24
CAS Registry Number 949142-50-1
NCIT ID C70741

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + Glofitamab-gxbm + Obinutuzumab Acalabrutinib Glofitamab-gxbm Obinutuzumab 0 1
Acalabrutinib + Obinutuzumab Acalabrutinib Obinutuzumab 2 6
Acalabrutinib + Obinutuzumab + Tafasitamab-cxix Acalabrutinib Obinutuzumab Tafasitamab-cxix 0 1
Acalabrutinib + Obinutuzumab + Venetoclax Acalabrutinib Obinutuzumab Venetoclax 0 5
ACE1831 + Cyclophosphamide + Fludarabine + Obinutuzumab ACE1831 Cyclophosphamide Fludarabine Obinutuzumab 0 1
Aldesleukin + Cyclophosphamide + Fludarabine + FT516 + Obinutuzumab Aldesleukin Cyclophosphamide FT516 Fludarabine Obinutuzumab 0 1
Atezolizumab + Bendamustine + Obinutuzumab Atezolizumab Bendamustine Obinutuzumab 0 1
Atezolizumab + Bevacizumab + Obinutuzumab + RO6874281 Atezolizumab Bevacizumab Obinutuzumab RO6874281 0 1
Atezolizumab + Cyclophosphamide + Doxorubicin + Obinutuzumab + Prednisone + Vincristine Sulfate Atezolizumab Cyclophosphamide Doxorubicin Obinutuzumab Prednisone Vincristine Sulfate 0 1
Atezolizumab + Glofitamab-gxbm + Obinutuzumab Atezolizumab Glofitamab-gxbm Obinutuzumab 0 1
Atezolizumab + Glofitamab-gxbm + Obinutuzumab + Tocilizumab Atezolizumab Glofitamab-gxbm Obinutuzumab Tocilizumab 0 1
Atezolizumab + Lenalidomide + Obinutuzumab Atezolizumab Lenalidomide Obinutuzumab 0 1
Atezolizumab + Obinutuzumab Atezolizumab Obinutuzumab 0 3
Atezolizumab + Obinutuzumab + Polatuzumab vedotin-piiq Atezolizumab Obinutuzumab Polatuzumab vedotin-piiq 0 1
Atezolizumab + Obinutuzumab + RO6874281 Atezolizumab Obinutuzumab RO6874281 0 1
Atezolizumab + Obinutuzumab + RO6958688 Atezolizumab Obinutuzumab RO6958688 0 1
Atezolizumab + Obinutuzumab + Venetoclax Atezolizumab Obinutuzumab Venetoclax 0 1
Azacitidine + Lenalidomide + Obinutuzumab Azacitidine Lenalidomide Obinutuzumab 0 1
Azacitidine + Obinutuzumab + Venetoclax Azacitidine Obinutuzumab Venetoclax 0 1
Bendamustine + Obinutuzumab Bendamustine Obinutuzumab 0 7
Bendamustine + Obinutuzumab + Parsaclisib Bendamustine Obinutuzumab Parsaclisib 0 1
Bendamustine + Obinutuzumab + Venetoclax Bendamustine Obinutuzumab Venetoclax 0 3
Bendamustine + Obinutuzumab + Venetoclax + Zanubrutinib Bendamustine Obinutuzumab Venetoclax Zanubrutinib 0 1
Carboplatin + Etoposide + Glofitamab-gxbm + Ifosfamide + Obinutuzumab + Rituximab Carboplatin Etoposide Glofitamab-gxbm Ifosfamide Obinutuzumab Rituximab 0 1
Carboplatin + Etoposide + Glofitamab-gxbm + Ifosfamide + Obinutuzumab + Rituximab + Tocilizumab Carboplatin Etoposide Glofitamab-gxbm Ifosfamide Obinutuzumab Rituximab Tocilizumab 0 1
Carboplatin + Etoposide + Ifosfamide + Obinutuzumab Carboplatin Etoposide Ifosfamide Obinutuzumab 0 1
CC-99282 + Obinutuzumab CC-99282 Obinutuzumab 0 2
Chlorambucil + Obinutuzumab Chlorambucil Obinutuzumab 0 4
Chlorambucil + Obinutuzumab + Umbralisib Chlorambucil Obinutuzumab Umbralisib 0 1
Copanlisib + Obinutuzumab Copanlisib Obinutuzumab 0 1
Cyclophosphamide + Doxorubicin + Glofitamab-gxbm + Obinutuzumab + Prednisone + Vincristine Sulfate Cyclophosphamide Doxorubicin Glofitamab-gxbm Obinutuzumab Prednisone Vincristine Sulfate 0 1
Cyclophosphamide + Doxorubicin + Obinutuzumab + Prednisone + Vincristine Sulfate Cyclophosphamide Doxorubicin Obinutuzumab Prednisone Vincristine Sulfate 0 4
Cyclophosphamide + Fludarabine + FT596 + Obinutuzumab Cyclophosphamide FT596 Fludarabine Obinutuzumab 0 1
Cyclophosphamide + Fludarabine + Ibrutinib + Obinutuzumab Cyclophosphamide Fludarabine Ibrutinib Obinutuzumab 0 1
Cyclophosphamide + Fludarabine + Obinutuzumab Cyclophosphamide Fludarabine Obinutuzumab 0 0
Docetaxel + Naptumomab estafenatox + Obinutuzumab Docetaxel Naptumomab estafenatox Obinutuzumab 0 1
Duvelisib + Obinutuzumab Duvelisib Obinutuzumab 0 1
Entospletinib + Obinutuzumab Entospletinib Obinutuzumab 0 1
Entospletinib + Obinutuzumab + Tirabrutinib Entospletinib Obinutuzumab Tirabrutinib 0 1
Glofitamab-gxbm + Ibrutinib + Obinutuzumab Glofitamab-gxbm Ibrutinib Obinutuzumab 0 1
Glofitamab-gxbm + Lenalidomide + Obinutuzumab Glofitamab-gxbm Lenalidomide Obinutuzumab 0 1
Glofitamab-gxbm + Lenalidomide + Obinutuzumab + Venetoclax Glofitamab-gxbm Lenalidomide Obinutuzumab Venetoclax 0 1
Glofitamab-gxbm + Obinutuzumab Glofitamab-gxbm Obinutuzumab 0 5
Glofitamab-gxbm + Obinutuzumab + Pirtobrutinib Glofitamab-gxbm Obinutuzumab Pirtobrutinib 0 1
Glofitamab-gxbm + Obinutuzumab + Polatuzumab vedotin-piiq Glofitamab-gxbm Obinutuzumab Polatuzumab vedotin-piiq 0 2
Glofitamab-gxbm + Obinutuzumab + Polatuzumab vedotin-piiq + Rituximab Glofitamab-gxbm Obinutuzumab Polatuzumab vedotin-piiq Rituximab 0 1
Glofitamab-gxbm + Obinutuzumab + Polatuzumab vedotin-piiq + Tocilizumab Glofitamab-gxbm Obinutuzumab Polatuzumab vedotin-piiq Tocilizumab 0 1
Glofitamab-gxbm + Obinutuzumab + RO7227166 + Tocilizumab Glofitamab-gxbm Obinutuzumab RO7227166 Tocilizumab 0 1
Glofitamab-gxbm + Obinutuzumab + RO7443904 Glofitamab-gxbm Obinutuzumab RO7443904 0 1
Glofitamab-gxbm + Obinutuzumab + RO7443904 + Tocilizumab Glofitamab-gxbm Obinutuzumab RO7443904 Tocilizumab 0 1
Glofitamab-gxbm + Obinutuzumab + Tocilizumab Glofitamab-gxbm Obinutuzumab Tocilizumab 0 1
Glofitamab-gxbm + Obinutuzumab + TTI-622 Glofitamab-gxbm Obinutuzumab TTI-622 0 1
Glofitamab-gxbm + Obinutuzumab + Venetoclax Glofitamab-gxbm Obinutuzumab Venetoclax 0 1
Glofitamab-gxbm + Obinutuzumab + Venetoclax + Zanubrutinib Glofitamab-gxbm Obinutuzumab Venetoclax Zanubrutinib 0 1
Hu5F9-G4 + Obinutuzumab + Venetoclax Hu5F9-G4 Obinutuzumab Venetoclax 0 1
Iberdomide + Obinutuzumab Iberdomide Obinutuzumab 0 1
Ibrutinib + Lenalidomide + Obinutuzumab + Polatuzumab vedotin-piiq + Prednisone + Venetoclax Ibrutinib Lenalidomide Obinutuzumab Polatuzumab vedotin-piiq Prednisone Venetoclax 0 1
Ibrutinib + Lenalidomide + Obinutuzumab + Prednisone + Venetoclax Ibrutinib Lenalidomide Obinutuzumab Prednisone Venetoclax 0 2
Ibrutinib + Obinutuzumab Ibrutinib Obinutuzumab 0 9
Ibrutinib + Obinutuzumab + Venetoclax Ibrutinib Obinutuzumab Venetoclax 0 5
Idasanutlin + Obinutuzumab Idasanutlin Obinutuzumab 0 1
Idasanutlin + Obinutuzumab + Rituximab + Venetoclax Idasanutlin Obinutuzumab Rituximab Venetoclax 0 1
Idasanutlin + Obinutuzumab + Venetoclax Idasanutlin Obinutuzumab Venetoclax 0 1
Idelalisib + Obinutuzumab Idelalisib Obinutuzumab 0 1
Idelalisib + Obinutuzumab + Tirabrutinib Idelalisib Obinutuzumab Tirabrutinib 0 1
Lenalidomide + Obinutuzumab Lenalidomide Obinutuzumab 0 2
Lenalidomide + Obinutuzumab + Polatuzumab vedotin-piiq Lenalidomide Obinutuzumab Polatuzumab vedotin-piiq 0 1
Lenalidomide + Obinutuzumab + Venetoclax Lenalidomide Obinutuzumab Venetoclax 0 2
Methylprednisolone + Obinutuzumab Methylprednisolone Obinutuzumab 2 0
Mosunetuzumab-axgb + Obinutuzumab + Polatuzumab vedotin-piiq Mosunetuzumab-axgb Obinutuzumab Polatuzumab vedotin-piiq 0 1
Obinutuzumab Obinutuzumab 2 22
Obinutuzumab + Otlertuzumab Obinutuzumab Otlertuzumab 0 1
Obinutuzumab + Pinatuzumab Vedotin + Rituximab Obinutuzumab Pinatuzumab Vedotin Rituximab 0 1
Obinutuzumab + Pirtobrutinib Obinutuzumab Pirtobrutinib 0 1
Obinutuzumab + Pirtobrutinib + Venetoclax Obinutuzumab Pirtobrutinib Venetoclax 0 1
Obinutuzumab + Polatuzumab vedotin-piiq Obinutuzumab Polatuzumab vedotin-piiq 0 1
Obinutuzumab + Polatuzumab vedotin-piiq + Rituximab Obinutuzumab Polatuzumab vedotin-piiq Rituximab 0 1
Obinutuzumab + Polatuzumab vedotin-piiq + Venetoclax Obinutuzumab Polatuzumab vedotin-piiq Venetoclax 0 1
Obinutuzumab + rhIL-15 Obinutuzumab rhIL-15 0 1
Obinutuzumab + Rituximab + Venetoclax Obinutuzumab Rituximab Venetoclax 0 1
Obinutuzumab + RO6958688 + RO7122290 Obinutuzumab RO6958688 RO7122290 0 1
Obinutuzumab + RO7227166 + Tocilizumab Obinutuzumab RO7227166 Tocilizumab 0 1
Obinutuzumab + RO7293583 + Tocilizumab Obinutuzumab RO7293583 Tocilizumab 0 1
Obinutuzumab + ST-067 Obinutuzumab ST-067 0 1
Obinutuzumab + Tocilizumab Obinutuzumab Tocilizumab 0 0
Obinutuzumab + Umbralisib Obinutuzumab Umbralisib 0 1
Obinutuzumab + Vemurafenib Obinutuzumab Vemurafenib 0 2
Obinutuzumab + Venetoclax Obinutuzumab Venetoclax 3 16
Obinutuzumab + Venetoclax + Zanubrutinib Obinutuzumab Venetoclax Zanubrutinib 0 3
Obinutuzumab + Zanubrutinib Obinutuzumab Zanubrutinib 0 3


Additional content available in CKB BOOST