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Drug Name | Obinutuzumab |
Trade Name | Gazyva |
Synonyms | R7159|afutuzumab|GA101|GA-101|RO 5072759 |
Drug Descriptions |
Gazyva (obinutuzumab) is a glycoengineered anti-CD20 antibody that binds to CD20 on B-cells, resulting in increased antibody-dependent cellular cytotoxicity and induction of apoptosis, and potentially leading to decreased growth of B-cell tumors (PMID: 20194898, PMID: 21220500). Gazyva (obinutuzumab) is FDA approved in combination with Ambochlorin (chlorambucil) for chronic lymphocytic leukemia and in combination with Treanda (bendamustine) or chemotherapy for follicular lymphoma (FDA.gov). |
DrugClasses | CD20 Antibody 24 |
CAS Registry Number | 949142-50-1 |
NCIT ID | C70741 |