EGFRt/19-28z/4-1BBL CAR T cells
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| Drug Name | EGFRt/19-28z/4-1BBL CAR T cells |
| Trade Name | |
| Synonyms | |
| Drug Descriptions |
EGFRt/19-28z/4-1BBL CAR T cells are autologous T-cells engineered to express TNFSF9 (4-1BBL) and a chimeric antigen receptor (CAR) targeting CD19 linked to CD28 and CD3zeta signaling domains as well as a truncated EGFR, which may relieve immunosuppression and enhance cytotoxicity against CD19-expressing tumor cells (NCI Thesaurus). |
| DrugClasses | CD19 Immune Cell Therapy 73 |
| CAS Registry Number | NA |
| NCIT ID | C133189 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| EGFRt/19-28z/4-1BBL CAR T cells | EGFRt/19-28z/4-1BBL CAR T cells | 0 | 1 |
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