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Therapy Name EGFRt/19-28z/4-1BBL CAR T cells
Synonyms
Therapy Description

EGFRt/19-28z/4-1BBL CAR T cells are autologous T-cells engineered to express TNFSF9 (4-1BBL) and a chimeric antigen receptor (CAR) targeting CD19 linked to CD28 and CD3zeta signaling domains as well as a truncated EGFR, which may relieve immunosuppression and enhance cytotoxicity against CD19-expressing tumor cells (NCI Thesaurus).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
EGFRt/19-28z/4-1BBL CAR T cells CD19 Immune Cell Therapy 62 EGFRt/19-28z/4-1BBL CAR T cells are autologous T-cells engineered to express TNFSF9 (4-1BBL) and a chimeric antigen receptor (CAR) targeting CD19 linked to CD28 and CD3zeta signaling domains as well as a truncated EGFR, which may relieve immunosuppression and enhance cytotoxicity against CD19-expressing tumor cells (NCI Thesaurus).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03085173 Phase I EGFRt/19-28z/4-1BBL CAR T cells A Trial of "Armored" CAR T Cells Targeting CD19 For Patients With Relapsed CD19+ Hematologic Malignancies Active, not recruiting USA 0


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