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Drug Name | 225Ac-J591 |
Trade Name | |
Synonyms | Ac 225 MOAB J591|Ac-225 Anti-PSMA J591|Ac-225 rosopatamab tetraxetan |
Drug Descriptions |
225Ac-J591 is a radioconjugate comprising the alpha-radiation emitting radionuclide actinium-225 linked to a monoclonal antibody that targets PSMA (J591), which delivers radiation to PSMA-expressing tumor cells, potentially resulting in antitumor activity (PMID: 37922438). |
DrugClasses | PSMA Antibody 20 |
CAS Registry Number | NA |
NCIT ID | C153159 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
225Ac-J591 | 225Ac-J591 | 0 | 5 |
225Ac-J591 + Pembrolizumab | 225Ac-J591 Pembrolizumab | 0 | 1 |
225Ac-J591 + PNT2002 | 225Ac-J591 PNT2002 | 0 | 1 |