CART-PSMA-TGF-beta RDN
Drug Detail
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| Drug Name | CART-PSMA-TGF-beta RDN |
| Trade Name | |
| Synonyms | Autologous PSMA-specific TGFb-resistant CAR T Cells |
| Drug Descriptions |
CART-PSMA-TGF-beta RDN is comprised of peripheral blood mononuclear cells engineered to express a dominant-negative TGFBRII lacking the kinase domain and a chimeric antigen receptor (CAR) that targets PSMA linked to the intracellular domains of 4-1BB and CD3zeta, which potentially induces killing of PSMA-expressing tumor cells and inhibits tumor growth (PMID: 29807781). |
| DrugClasses | |
| CAS Registry Number | NA |
| NCIT ID | C148496 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| CART-PSMA-TGF-beta RDN | CART-PSMA-TGF-beta RDN | 0 | 1 |
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