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Drug Name | CART-PSMA-TGF-beta RDN |
Trade Name | |
Synonyms | Autologous PSMA-specific TGFb-resistant CAR T Cells |
Drug Descriptions |
CART-PSMA-TGF-beta RDN is comprised of peripheral blood mononuclear cells engineered to express a dominant-negative TGFBRII lacking the kinase domain and a chimeric antigen receptor (CAR) that targets PSMA linked to the intracellular domains of 4-1BB and CD3zeta, which potentially induces killing of PSMA-expressing tumor cells and inhibits tumor growth (PMID: 29807781). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C148496 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
CART-PSMA-TGF-beta RDN | CART-PSMA-TGF-beta RDN | 0 | 1 |