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Therapy Name CART-PSMA-TGF-beta RDN
Synonyms
Therapy Description

CART-PSMA-TGF-beta RDN is comprised of peripheral blood mononuclear cells engineered to express a dominant-negative TGFBRII lacking the kinase domain and a chimeric antigen receptor (CAR) that targets PSMA linked to the intracellular domains of 4-1BB and CD3zeta, which potentially induces killing of PSMA-expressing tumor cells and inhibits tumor growth (PMID: 29807781).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CART-PSMA-TGF-beta RDN Autologous PSMA-specific TGFb-resistant CAR T Cells CART-PSMA-TGF-beta RDN is comprised of peripheral blood mononuclear cells engineered to express a dominant-negative TGFBRII lacking the kinase domain and a chimeric antigen receptor (CAR) that targets PSMA linked to the intracellular domains of 4-1BB and CD3zeta, which potentially induces killing of PSMA-expressing tumor cells and inhibits tumor growth (PMID: 29807781).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03089203 Phase I CART-PSMA-TGF-beta RDN Cyclophosphamide + Fludarabine CART-PSMA-TGFbetaRDN Cells for Castrate-Resistant Prostate Cancer Active, not recruiting USA 0


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