Chlorotoxin-CD28-CD3z-CD19t CART cells
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| Drug Name | Chlorotoxin-CD28-CD3z-CD19t CART cells |
| Trade Name | |
| Synonyms | Chlorotoxin (EQ)-CD28-CD3zeta-CD19t CART cell |
| Drug Descriptions |
Chlorotoxin-CD28-CD3z-CD19t CART cells consist of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) containing a CD28 co-stimulatory domain linked to the CD3zeta chain, a truncated CD19 (CD19t), a G4-Fc (EQ) immunoglobulin spacer, and a matrix metalloproteinase-2 (MMP-2) targeting chlorotoxin peptide, which potentially interferes with chloride transport and remodeling of extracellular matrix, and may induce cytotoxicity against tumor cells expressing MMP-2 and limit tumor cell spreading (NCI Thesaurus). |
| DrugClasses | |
| CAS Registry Number | NA |
| NCIT ID | C167056 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Chlorotoxin-CD28-CD3z-CD19t CART cells | Chlorotoxin-CD28-CD3z-CD19t CART cells | 0 | 1 |
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