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Therapy Name Chlorotoxin-CD28-CD3z-CD19t CART cells
Synonyms
Therapy Description

Chlorotoxin-CD28-CD3z-CD19t CART cells consist of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) containing a CD28 co-stimulatory domain linked to the CD3zeta chain, a truncated CD19 (CD19t), a G4-Fc (EQ) immunoglobulin spacer, and a matrix metalloproteinase-2 (MMP-2) targeting chlorotoxin peptide, which potentially interferes with chloride transport and remodeling of extracellular matrix, and may induce cytotoxicity against tumor cells expressing MMP-2 and limit tumor cell spreading (NCI Thesaurus).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Chlorotoxin-CD28-CD3z-CD19t CART cells Chlorotoxin (EQ)-CD28-CD3zeta-CD19t CART cell Chlorotoxin-CD28-CD3z-CD19t CART cells consist of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) containing a CD28 co-stimulatory domain linked to the CD3zeta chain, a truncated CD19 (CD19t), a G4-Fc (EQ) immunoglobulin spacer, and a matrix metalloproteinase-2 (MMP-2) targeting chlorotoxin peptide, which potentially interferes with chloride transport and remodeling of extracellular matrix, and may induce cytotoxicity against tumor cells expressing MMP-2 and limit tumor cell spreading (NCI Thesaurus).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04214392 Phase I Chlorotoxin-CD28-CD3z-CD19t CART cells Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the Treatment of MMP2+ Recurrent or Progressive Glioblastoma Active, not recruiting USA 0


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