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Gene Symbol EML4
Synonyms C2orf2 | ELP120 | EMAP-4 | EMAPL4 | ROPP120
Gene Description EML4, EMAP like 4, plays a role in microtubule formation and stability (PMID: 16890222) and is required for cell proliferation and survival (PMID: 31366041). The fusion protein of EML4-ALK results in transformation activity and is present in a small percentage of patients with non-small cell lung cancer (PMID: 17625570, PMID: 23341890, PMID: 31366041, PMID: 31432686) and has also been reported in pulmonary atypical carcinoid (PMID: 31559892) and cholangiocarcinoma (PMID: 31711728).

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Molecular Profile Protein Effect Treatment Approaches
EML4 E127* loss of function - predicted
EML4 - ALK gain of function ALK Inhibitor
EML4 - ALK ALK G1269A Alectinib AZD3463 Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK L1196M Brigatinib Ceritinib Ensartinib Entrectinib Lorlatinib Repotrectinib
EML4 - ALK ALK C1156Y Alectinib Brigatinib Ensartinib Lorlatinib
EML4 - ALK ALK S1206Y Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK G1202R Brigatinib Lorlatinib
EML4 - ALK ALK I1171T Ceritinib Lorlatinib TAE684
EML4 - ALK ALK L1152R Brigatinib Lorlatinib
EML4 - ALK ALK V1180L ASP3026 Brigatinib Ceritinib Lorlatinib TAE684
EML4 - ALK ALK I1171S Lorlatinib
EML4 - ALK ALK T1151M Alectinib AZD3463 Brigatinib Crizotinib
EML4 - ALK ALK F1174L Alectinib AZD3463 Lorlatinib
EML4 - ALK ALK R1192P Alectinib AZD3463 Brigatinib Crizotinib
EML4 - ALK ALK E1210K Alectinib Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK C1156Y ALK L1198F Crizotinib
EML4 - ALK ALK L1198F Brigatinib Crizotinib
EML4 - ALK ALK F1174C Brigatinib Lorlatinib
EML4 - ALK ALK F1174C ALK L1198F Crizotinib
EML4 - ALK ALK L1196M ALK L1198F
EML4 - ALK ALK L1198F ALK G1202R Crizotinib
EML4 - ALK ALK L1198F ALK G1269A Brigatinib Crizotinib
EML4 - ALK ALK I1171N Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK G1202del Lorlatinib
EML4 - ALK ALK D1203N Alectinib Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK F1174C ALK D1203N
EML4 - ALK ALK D1203N ALK E1210K Lorlatinib
EML4 - ALK ALK S1206F Brigatinib
EML4 - ALK ALK L1152P Brigatinib
EML4 - ALK ALK T1151dup Brigatinib
EML4 - ALK ALK F1174V Alectinib Brigatinib
EML4 - ALK ALK F1245C Ceritinib
EML4 - ALK ALK I1171S ALK F1174V
EML4 - ALK ALK L1196M ALK G1269A
EML4 - ALK ALK C1156Y ALK L1196M
EML4 - ALK ALK L1198P
EML4 - ALK ALK F1174V ALK G1202R
EML4 - ALK MAP2K1 K57N
EML4 - ALK ALK C1156Y ALK I1171T
EML4 - ALK ALK C1156Y ALK F1174C
EML4 - ALK ALK C1156Y ALK F1174I
EML4 - ALK ALK C1156Y ALK F1174V
EML4 - ALK ALK C1156Y ALK D1203N
EML4 - ALK ALK C1156Y ALK L1256F
EML4 - ALK ALK C1156Y ALK G1269A
EML4 - ALK ALK I1171S ALK L1196M
EML4 - ALK ALK F1174C ALK L1196M
EML4 - ALK ALK F1174L ALK L1196M
EML4 - ALK ALK F1174V ALK L1196M
EML4 - ALK ALK I1179V ALK L1196M
EML4 - ALK ALK L1196M ALK L1198H
EML4 - ALK ALK L1196M ALK L1256F
EML4 - ALK ALK F1174C ALK G1269A
EML4 - ALK ALK L1196M ALK G1202R
EML4 - ALK ALK I1171T ALK G1269A
EML4 - ALK ALK I1171N ALK G1269A
EML4 - ALK ALK S1206C ALK E1210K
EML4 - ALK ALK F1174L ALK L1198V
EML4 - ALK FGFR1 amp
EML4 - ALK HRAS amp
EML4 - ALK ALK F1174L ALK G1269A
EML4 - ALK ALK F1174L ALK D1203N ALK G1269A
EML4 - ALK ALK E1303K
EML4 - ALK ALK L1256F
EML4 - ALK ALK E1154K ALK G1202R ALK I1268V
EML4 - ALK ALK T1151M ALK C1156Y ALK F1174L ALK G1202R ALK S1206F ALK G1269A
EML4 - ALK ALK F1174L ALK G1202R
EML4 - ALK ALK L1196M ALK D1203N
EML4 - ALK ALK I1171S ALK G1269A
EML4 - ALK ALK G1269S
EML4 - ALK ALK C1156Y ALK G1202R
EML4 - ALK ALK G1202R ALK G1269A
EML4 - ALK ALK G1202R ALK L1204V ALK G1269A
EML4 - ALK ALK L1198F ALK G1202R ALK G1269A
EML4 - ALK ALK L1196Q
EML4 - ALK ALK T1151K
EML4 - ALK ALK I1171N ALK L1256F
EML4 - ALK ALK I1171N ALK F1174I
EML4 - ALK ALK I1171N ALK L1198H
EML4 - ALK ALK F1174I
EML4 - ALK ALK F1245V
EML4 - ALK ALK I1171N ALK F1174L
EML4 - ALK ALK I1171N ALK L1198F
EML4 - ALK ALK I1171N ALK L1196M
EML4 - ALK ALK D1203N ALK F1245V
EML4 - ALK TP53 Q331*
EML4 - ALK TP53 V274fs
EML4 - ALK ALK S1206R
EML4 - ALK ALK Q1188_L1190del
EML4 - ALK ALK G1202K
EML4 - ALK ALK A1200_G1201delinsW
EML4 - ALK ALK V1180L ALK G1202R
EML4 - ALK ALK C1156Y ALK L1196M ALK G1202R
ARID2 - ALK EML4 - ALK
EML4 - ALK ALK L1319V
EML4 - ALK ALK I1171N ALK V1180L
EML4 - ALK ALK F1174C ALK E1210K
EML4 - ALK ALK I1171N ALK L1196M ALK G1202R
EML4 - ALK ALK I1171N ALK D1203N
EML4 - ALK ALK G1202R ALK S1206F
EML4 - ALK ALK G1202R ALK S1206F ALK G1269A
EML4 - ALK ALK T1151K ALK G1202R ALK S1206F
EML4 - ALK ALK G1202L
EML4 - ALK ALK R1275Q
EML4 - ALK ALK E1129V ALK I1171T ALK F1174C ALK F1174L ALK F1174V ALK G1269A
EML4 - ALK BRAF V600E
EML4 - ALK ALK E1129V
EML4 - ALK ALK I1171T ALK F1174V
EML4 - ALK ALK L1196M ALK G1202R ALK D1203N
EML4 - ALK ALK E1129V ALK G1202R
EML4 - ALK ALK F1174C ALK G1202R
EML4 - ALK ALK F1174I ALK G1202R
EML4 - ALK ALK E1129V ALK I1171N
EML4 - ALK ALK C1156Y ALK I1171N
EML4 - ALK BRAF A598_T599insV
EML4 - ALK ALK F1174L ALK S1189C
EML4 - ALK ALK T1151M ALK G1202R
EML4 - ALK ALK V1180Y
EML4 - ALK ALK I1171N ALK G1202R
EML4 - ALK ALK F1174L ALK E1210K ALK G1269A
EML4 - ALK ALK I1171T ALK F1174L ALK L1196M ALK D1203N ALK E1210K ALK G1269A
EML4 - ALK ALK F1174L ALK E1210K
EML4 - ALK ALK A1200V
EML4 - ALK IDH2 R140Q
EML4 - ALK ALK G1123S
EML4 - ALK ALK C1156Y ALK I1171N ALK L1198F
EML4 - ALK ALK C1156Y ALK I1171T ALK L1198F
EML4 - ALK ALK L1196P
EML4 - ALK ALK L1198R
EML4 - ALK ALK C1237Y
EML4 - ALK ALK C1235R ALK C1237Y
EML4 - ALK ALK R1181H
EML4 - ALK ALK G1128A ALK R1192P
EML4 - ALK ALK P1094H
EML4 - ALK ALK F1174C ALK V1180L
EML4 - ALK ALK L1122V ALK L1196M ALK D1203N ALK G1269A
EML4 - ALK ALK E803Q ALK V1180L
EML4 - RET gain of function - predicted
EML4 fusion unknown
EML4 inact mut loss of function
EML4 mutant unknown
EML4 wild-type no effect