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Gene Symbol RAD51B
Synonyms R51H2 | RAD51L1 | REC2
Gene Description RAD51B, RAD51 paralog B, plays a role in homologous recombination repair of double-strand DNA breaks (PMID: 21821141, PMID: 32098697). RAD51B mutations are associated with susceptibility to breast cancer (PMID: 24139550, PMID: 29255180) and overexpression has been correlated with a favorable prognosis in non-small cell lung cancer (PMID: 29207658) and a poor prognosis in gastric cancer (PMID: 27651161).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
5890 14 14q24.1 NM_133509 Tumor suppressor (PMID: 30606230)

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51B wild-type breast cancer not applicable N/A Preclinical Emerging SiRNA inhibition of RAD51B in breast cancer cells resulted in increased sensitivity to DNA damaging agents in culture, suggesting that RAD51B could be a promising therapeutic target for sensitization to chemotherapeutic agents in combination therapies (PMID: 25368520). 25368520
RAD51B wild-type ovary serous adenocarcinoma predicted - sensitive Cediranib + Olaparib Clinical Study - Cohort Actionable In a Phase II trial, Cediranib (AZD-2171) and Lynparza (olaparib) treatment was well tolerated, and resulted in an objective response rate (ORR) of 9% (all partial), a 16-week progression-free survival (PFS) of 47%, and a disease control rate (DCR) of 68% in high-grade serous ovarian cancer patients (n=34), and a median PFS of 6.4 months and 1.9 months in patients harboring wild-type (n=9) and reversion mutations (n=5) in either BRCA1, BRCA2, or RAD51B, respectively (PMID: 32444417; NCT02681237). 32444417
RAD51B inact mut prostate cancer sensitive Olaparib FDA approved - On Companion Diagnostic Actionable In a Phase III trial (PROfound) that supported FDA approval, Lynparza (olaparib) treatment significantly improved median imaging-based progression-free survival (5.8 vs 3.5 mo, HR 0.49, p<0.001) compared to control in patients with metastatic castration-resistant prostate cancer who progressed on hormone therapy and harbored deleterious or suspected deleterious mutations in homologous recombination repair genes, including RAD51B (PMID: 32343890; NCT02987543). detail... detail... 32343890
RAD51B inact mut prostate cancer sensitive Olaparib Guideline Actionable Lynparza (olaparib) is included in guidelines as second-line therapy post androgen receptor-directed therapy for patients with metastatic castration-resistant prostate cancer harboring pathogenic mutations in RAD51B (NCCN.org). detail...
RAD51B mutant ovary serous adenocarcinoma predicted - sensitive Cediranib + Olaparib Clinical Study - Cohort Actionable In a Phase II trial, Cediranib (AZD-2171) and Lynparza (olaparib) treatment was well tolerated, and resulted in an objective response (OR) of 9% (all partial), a 16-week progression-free survival (PFS) of 47%, and a disease control rate (DCR) of 68% in heavily pretreated high-grade serous ovarian cancer patients (n=34), and a median PFS of 4.8 months in patients (n=14) harboring mutations in either BRCA1, BRCA2, or RAD51B (PMID: 32444417; NCT02681237). 32444417
RAD51B del uterus leiomyosarcoma predicted - sensitive Olaparib + Temozolomide Case Reports/Case Series Actionable In a clinical case study, Lynparza (olaparib) and Temodar (temozolomide) combination treatment resulted in stable disease and progression-free survival lasting 980 days in a patient with advanced uterine leiomyosarcoma harboring a homozygous deletion of RAD51B (PMID: 37467452). 37467452
RAD51B rearrange prostate cancer predicted - sensitive Rucaparib Case Reports/Case Series Actionable In a Phase II trial (TRITON2), a patient with metastatic castrate-resistant prostate cancer harboring a RAD51B rearrangement demonstrated a PSA response and partial radiographic response after treatment with Rubraca (rucaparib), which were ongoing at the time of visit cutoff (PMID: 32086346; NCT02952534). 32086346