NTRK2 M713I
Gene Variant Detail

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Gene NTRK2
Variant M713I
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions NTRK2 M713I (corresponds to M697I in the canonical isoform) lies within the protein kinase domain of the Ntrk2 protein (UniProt.org). M713I results in loss of Ntrk2 autophosphorylation, decreased phosphorylation of Ntrk2, Akt and Erk upon growth factor stimulation, is not transforming in cell culture, and is associated with resistance to a Trk inhibitor (PMID: 21242122).
Associated Drug Resistance Y
Category Variants Paths

NTRK2 mutant NTRK2 inact mut NTRK2 M713I

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Transcript NM_006180.6
gDNA chr9:g.84955484G>C
cDNA c.2139G>C
Protein p.M713I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005252004.2 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
NM_006180.4 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
XM_017014751.2 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
XM_005252001.3 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
NM_006180.6 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
XM_047423432.1 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
XM_005252001.4 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
XM_005252004 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
XM_047423433.1 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
XM_005252003.4 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
XM_017014751 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
XM_005252004.3 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
NM_006180 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
XM_017014751.3 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
XM_005252003 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
XM_005252001 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38
XM_005252003.3 chr9:g.84955484G>C c.2139G>C p.M713I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK2 M713I Advanced Solid Tumor resistant AZD6918 Preclinical Actionable In a preclinical study, a transformed cell line expressing NTRK2 M713I was resistant to inhibition of Ntrk2 autophosphorylation and BDNF-induced cell proliferation by AZD6918 treatment in culture (PMID: 21242122). 21242122