TSC1 loss
Gene Variant Detail

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Gene TSC1
Variant loss
Impact List unknown
Protein Effect loss of function
Gene Variant Descriptions TSC1 loss indicates loss of the TSC1 gene, mRNA, and protein.
Associated Drug Resistance
Category Variants Paths

TSC1 mutant TSC1 inact mut TSC1 loss

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TSC1 loss urinary bladder cancer sensitive Sirolimus Preclinical Actionable In a preclinical study, Rapamune (sirolimus) inhibited proliferation of cultured bladder cancer cells lacking TSC1 (PMID: 23401075). 23401075
TSC1 loss urinary bladder cancer sensitive Torin 1 Preclinical Actionable In a preclinical study, Torin 1 inhibited proliferation of cultured bladder cancer cells lacking TSC1 (PMID: 23401075). 23401075
TSC1 loss urinary bladder cancer sensitive Luminespib + Sirolimus Preclinical Actionable In a preclinical study, Luminespib (AUY922), in combination with Rapamune (sirolimus), inhibited growth of bladder cancer cells lacking TSC1 to a greater extent than either therapy alone (PMID: 23401075). 23401075
TSC1 loss urinary bladder cancer sensitive Luminespib + Torin 1 Preclinical Actionable In a preclinical study, Luminespib (AUY922), in combination with Torin 1 inhibited growth of bladder cancer cells lacking TSC1 to a greater extent than either therapy alone (PMID: 23401075). 23401075