BRIP1 A745P
Gene Variant Detail

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Gene BRIP1
Variant A745P
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRIP1 A745P does not lie within any known functional domains of the Brip1 protein (UniProt.org). A745P has been identified in sequencing studies (PMID: 25122427), but has not been biochemically characterized and therefore, its effect on Brip1 protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

BRIP1 mutant BRIP1 A745P

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Transcript NM_032043.3
gDNA chr17:g.61744456C>G
cDNA c.2233G>C
Protein p.A745P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047436897.1 chr17:g.61744456C>G c.2233G>C p.A745P RefSeq GRCh38/hg38
NM_032043 chr17:g.61744456C>G c.2233G>C p.A745P RefSeq GRCh38/hg38
XM_047436901.1 chr17:g.61744456C>G c.2233G>C p.A745P RefSeq GRCh38/hg38
XM_047436896.1 chr17:g.61744456C>G c.2233G>C p.A745P RefSeq GRCh38/hg38
XM_047436899.1 chr17:g.61744456C>G c.2233G>C p.A745P RefSeq GRCh38/hg38
XM_011525335.3 chr17:g.61744456C>G c.2233G>C p.A745P RefSeq GRCh38/hg38
XM_047436900.1 chr17:g.61744456C>G c.2233G>C p.A745P RefSeq GRCh38/hg38
NM_032043.3 chr17:g.61744456C>G c.2233G>C p.A745P RefSeq GRCh38/hg38
XM_047436891.1 chr17:g.61744456C>G c.2233G>C p.A745P RefSeq GRCh38/hg38
XM_011525335.4 chr17:g.61744456C>G c.2233G>C p.A745P RefSeq GRCh38/hg38
XM_047436892.1 chr17:g.61744456C>G c.2233G>C p.A745P RefSeq GRCh38/hg38
XM_011525335 chr17:g.61744456C>G c.2233G>C p.A745P RefSeq GRCh38/hg38
NM_032043.2 chr17:g.61744456C>G c.2233G>C p.A745P RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRIP1 mutant ovarian cancer not applicable N/A Guideline Risk Factor Germline BRIP1 mutations are associated with increased risk of developing ovarian cancer (NCCN.org). detail...