BRIP1 A745T
Gene Variant Detail

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Gene BRIP1
Variant A745T
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRIP1 A745T does not lie within any known functional domains of the Brip1 protein (UniProt.org). A745T does not result in chromosomal aberrations, leads to cell cycle effects similar to wild-type Brip1 upon treatment with DNA damaging agents, and demonstrates resistance to mitomycin treatment in BRIP1-deficient cells in culture (PMID: 31822495), and therefore, is predicted to have no effect on Brip1 protein function.
Associated Drug Resistance
Category Variants Paths

BRIP1 mutant BRIP1 A745T

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Transcript NM_032043.3
gDNA chr17:g.61744456C>T
cDNA c.2233G>A
Protein p.A745T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047436897.1 chr17:g.61744456C>T c.2233G>A p.A745T RefSeq GRCh38/hg38
XM_047436899.1 chr17:g.61744456C>T c.2233G>A p.A745T RefSeq GRCh38/hg38
XM_047436891.1 chr17:g.61744456C>T c.2233G>A p.A745T RefSeq GRCh38/hg38
NM_032043 chr17:g.61744456C>T c.2233G>A p.A745T RefSeq GRCh38/hg38
XM_047436900.1 chr17:g.61744456C>T c.2233G>A p.A745T RefSeq GRCh38/hg38
XM_011525335.4 chr17:g.61744456C>T c.2233G>A p.A745T RefSeq GRCh38/hg38
NM_032043.2 chr17:g.61744456C>T c.2233G>A p.A745T RefSeq GRCh38/hg38
XM_011525335.3 chr17:g.61744456C>T c.2233G>A p.A745T RefSeq GRCh38/hg38
NM_032043.3 chr17:g.61744456C>T c.2233G>A p.A745T RefSeq GRCh38/hg38
XM_047436901.1 chr17:g.61744456C>T c.2233G>A p.A745T RefSeq GRCh38/hg38
XM_011525335 chr17:g.61744456C>T c.2233G>A p.A745T RefSeq GRCh38/hg38
XM_047436892.1 chr17:g.61744456C>T c.2233G>A p.A745T RefSeq GRCh38/hg38
XM_047436896.1 chr17:g.61744456C>T c.2233G>A p.A745T RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRIP1 mutant ovarian cancer not applicable N/A Guideline Risk Factor Germline BRIP1 mutations are associated with increased risk of developing ovarian cancer (NCCN.org). detail...